Consortium

The InnovaBone consortium is composed of a unique, multidisciplinary blend of immunologists, cell biologists, phamacologists, molecular biologists, chemists, physicists, tissue engineers, medical doctors and laser technology engineers, business consultants with extensive state-of-the-art expertise. The consortium participants belong to 8 EU member states.

It consists of 8 Universities, 2 National and International research institutes, 5 SMEs and one large industrial partner.

InnovaBone uses the expertise and infrastructure available from each partner to exert a highly integrative, concerted and unified effort to develop a novel, highly marketable bioinspired product for clinical medicine. Select a country to discover its partners.

UNIVIE - Universität Wien Althanstrasse 14 1090 Wien

CONTACT PERSON Prof. Oskar Hoffmann

The University of Vienna was founded in 1365 and is the oldest university in the German-speaking world and one of the largest in Central Europe. At present, about 85,000 students are enrolled at the University of Vienna, in 182 courses. The University of Vienna is also the largest teaching and research institution in Austria with close to 8,600 employees, 6,500 of which are scientists and academics. The Department of Pharmacology and Toxicology is one of several institutes in the Pharmazie-Zentrum (Pharmacy Centre) in the Life Sciences Faculty of the University of Vienna with a vast array of technology available under one roof including, proteomics, analytical chemistry, molecular biology, genomics, transcriptomics, metabolomics and physiomics. The bone group at the department of Pharmacology and Toxicology is equipped with a cell culture facility, animal facility, isotope lab, image analysis system, fluorescence microscope and a confocal laser scanning unit.

IBA - Institut für Bioprozess- und Analysenmesstechnik e.V. Rosenhof, 37308 Heiligenstadt

CONTACT PERSON Prof. Klaus Liefeith

The IBA Heiligenstadt is a non-‐university public research institute located in Thuringia/Germany. The research profile focused onto the field of applied science is reflected as “BIOTECHNIQUES AT INTERFACES”.

B2 will lead WP1. The main function especially of the Department of Biomaterials of the B2 Heiligenstadt is to study interactions and their interpretation in terms of measurable material properties, making possible predictions about the behaviour of artificial or natural Biomaterials in contact with biological systems. Moreover, highly innovative techniques will be used to design, create and “tailor made” biomaterial properties to optimise cell material communication.

UCAM - THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Granta Place Mill Lane Cambridge CB2 1RU

CONTACT PERSON Prof. Serena Best

The Department of Materials Science and Metallurgy is one of the leading materials science departments in the world. It was awarded the top 5* rating in the most recent U.K. Research Assessment Exercise. The Department houses a wide range of state-of-the‐art research equipment in materials characterisation, its research covers a very wide range of materials, from creating new materials to improving existing materials. Professor William Bonfield created and established the Cambridge Centre for Medical Materials (CCMM), a multidisciplinary research centre with strong collaborations within the University of Cambridge in 2000. CCMM research focus is on the activities of materials processing, physico‐chemical characterisation and biological evaluation: a wide range of materials are included, from bioactive ceramics, biodegradable polymer to biocomposites, the applications cover from medical implants, drug delivery systems to tissue engineering.

UNOTT - THE UNIVERSITY OF NOTTINGHAM University Park Nottingham, NG7 2RD

CONTACT PERSON Prof. David Grant

The University of Nottingham's Biomaterials research lies the Advanced Materials Research group which one of 22 key research groups in the faculty of Engineering. The faculty of Engineering which has five research divisions and over 220 academic staff and was ranked 7th in the UK for engineering and technology while the University of Nottingham Nottingham is ranked 8th in the UK on a measure of "research power" which takes into account both the quality of research and the number of research-active staff who made REF returns. The Biomaterials reserach takes place in the Wolfson Building in the Faculty of enginnering where novel materials and structures are synthesised and characterised. Structures vary from nano composite, thin films through to macroscopic tissue engineered products based on synthetic and polymers, ceramics, glassses and metals. In addition to its own cell culturing facilities and explorations into cell surface interatctions the group works closely with the School of Medicine with their stem cell reserach and clinicians in orthopaedics. The Group also has had a number of national and international collaborations

QServe - Qserve Consultancy BV Asterweg 19 D12 unit 6, NL-1031 HL Amsterdam

CONTACT PERSON Willibrord Driessen

Qserve Consultancy BV is an independent Regulatory Compliance Consultancy Company, having an office in Europe (Amsterdam, the Netherlands).

Qserve's experts offer assistance/support in Strategic planning/development, Due diligence & GAP Analysis services, Product regulatory clearance (such as CE MARK, 510K, IND, PMA and more), preclinical, clinical support services, certified training, auditing (internal, supplier and distributor) and quality management systems implementation (ISO 13485 including Canadian CANCAS, FDA Quality Regulations (P5R, part $820). Preclinical studies, Planning of Electrical safety tests, Biocompatibility tests, Physical and mechanical tests, Animal studies, Stability/ shelf life testing and Sterilisation validation tests. Clinical Evaluation Studies, strategy, advice on and review of clinical investigation plans and clinical study protocols, investigators brochures, Selection of suitable physical testing, Writing your clinical procedures, Shelf life study, Clinical literature studies, Risk & Benefit studies, Post market clinical follow‐up (PMCF), Selection of Clinical Research Organisations and Agencies (CRO's & CRA's).

BAXTER - BAXTER INNOVATIONS GMBH Industriestraße 131, 1221 Vienna

CONTACT PERSON John Barry

BioScience, a division of Baxter Healthcare, creates products to improve surgical practice through the development and use of novel biomaterials for hard and soft tissue repair. Baxter has a number of marketed products in the orthopaedic space and is investing heavily in a long term pipeline of products where growth factors are mixed in or covalently attached to Baxter’s fibrin sealant product. Baxter was the first company to commercially produce a fibrin sealant product and today is the market leader. Due to its solid position in the market space, Baxter would be ideally suited to exploit any commercial product arising from the InnovoBone collaboration. R&D at Baxter consists of approx 80 FTE’s (Scientists/Vets and Technicians) with experience in Materials Science, Protein Chemistry and Cell Biology. Baxter has extensive technological resources available in-house to support these researchers and their activities.

TETRA - TETRA GESELLSCHAFT FUR SENSORIK ROBOTIK UND AUTOMATION MBH Gewerbepark "Am Wald 4", 98693 Ilmenau

CONTACT PERSON Olaf Mollenhauer

Gesellschaft für Sensorik, Robotik und Automation mbH, founded in 1991, specialises in standard and customised solutions and is a manufacturing and service provider in the following business segments: PRECISION MECHATRONICS Machines and components for precision automation; precision handling in the sub-µm range (resolution better than 10nm) by using precision drives and positioning systems, special sensors and image processing; special measuring and test units for applications in laser machining, coordinate measurement, wafer and solar cell inspection, etc. SENSORS / SCIENTIFIC DEVICES: Force and position measurement systems based on fibre optic and interferometric sensors in the nano range; scientific devices for analysis of material and surface properties, like friction, abrasion, adhesion, viscosity. ELECTRONIC CONTROL SYSTEMS: Development and production of control and communication devices based on newest micro controller systems (device controls, current supply, drive controls, remote controls, networks); analogue and digital circuit.

CSEM - CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT Rue Jaquet-Droz 1 CH-2002 Neuchâtel

CONTACT PERSON Martha Liley

Swiss Centre for Electronics and Microtechnology, founded in 1984 is an independent, private, non‐profit research and development centre specialised in microtechnology, nanotechnology, microelectronics, system engineering and communications technologies. It offers its customers and industry beneficiaries tailor-made innovative solutions based on its technological expertise. The division Nanotechnology and Life Sciences deals in particular with micro-optical components and nanoscale photonics for applications in lasers and spectrometers. Nanoscale structuring of surfaces and functional materials for improved optical and chemical surface properties, nanoporous membranes and security features. Micro- and nanoscale components for biological applications, such as cell studies, toxicology testing, improved implants and nanoscale tools that allow new approaches in biological research. Also innovative applications of biosensing for integrated and wearable sensing, in textiles, in food quality, diagnostics and health.

MUW - MEDIZINISCHE UNIVERSITAET WIEN Währinger Gürtel 18-20 4P9.02, LST 3P 1090 Vienna

CONTACT PERSON Dr. Michelle Epstein

The Medical University of Vienna is one of the largest Universities in Austria and one of the largest Medical Universities in Europe. It provides scientific work environment for approximately 3000 scientists and 2000 support and administrative personnel in medical and basic research fields. Basic financing provided by the state of Austria amounts to roughly €220 million per annum. Over 11000 students are enrolled in the study programs. Medical University Vienna is involved in delivering patient care to about 90000 patients in the stationary part of General Hospital of Vienna and to approximately 400.000 outpatients each year. Beneficiary 1 is at the MUW in the capacity of lab leader of the Experimental Allergy Lab within the Department of Dermatology. The laboratory is physically located at the Vienna Competence Centre, where there is contact and shared resources with researchers in the Centre for Molecular Medicine, and Institutes of Immunology, and Molecular Immunology. The building is located across from the Vienna General Hospital, which houses our main clinical department and contains a large number of researchers in clinical and basic science, several with whom we collaborate. We have laboratory and office space and a large array of technical equipment for executing the experiments and coordinating tasks outlined in this proposal. Our animal facilities that we use for current experiments will have sufficient space for the experiments that we planned for this proposal.

UVa - UNIVERSIDAD DE VALLADOLID Campus de Miguel Delibes Paseo de Belén 11, Valladolid

CONTACT PERSON Prof. José Carlos Rodríguez-Cabello

The Universidad de Valladolid team is a pioneer and world leading group in the use of genetic engineering and other molecular biology tools to obtain protein-like polymers and materials. By these techniques the team has already designed, bioproduced and characterised a wide set of highly functional genetically engineered protein polymers with absolute controlled molecular architecture and sequence. All those polymers are characterised by being tailored and multi(bio)functional including in their sequence various cell attachment sequences and other bioactive peptide domains. With the centre on those highly efficient materials, the UVa group has shaped a knowledge platform to create and characterise advanced systems and devices for biomedicine. That includes know-how on processing and obtaining substrates and hydrogels for tissue engineering, surface engineering for cell harvesting, guidance and confinement, fibres, nanofibres and derived fibrous scaffolds and systems and self‐assembling nanocarriers for advanced drug delivery. The Uva team hosts around 25 researchers and belongs to several networks dealing with tissue engineering and biomaterials: the Networking Regenerative Medicine and Cellular Therapy of Castilla y León or the Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN).

UPC - UNIVERSITAT POLITECNICA DE CATALUNYA C. Jordi Girona, 31. 08034 Barcelona

CONTACT PERSON Prof. Marìa Pau Ginebra

The Biomaterials, Biomechanics and Tissue Engineering Research Group is part of the Research Centre in Biomedical Engineering of the Technical University of Catalonia. It is an interdisciplinary group which hosts 25 researchers and focuses its interests in the development of biomaterials for the functional repair and reconstruction of biologic tissues, with special attention devoted to bioactive materials and surfaces.

UMG - UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - SdöR Robert-Koch-Straße 40 37075 Göttingen

CONTACT PERSON Prof. Frauke Alves

The University Medical Center of Göttingen (UMG) comprises the University Hospital and the Faculty of Medicine of the Georg-August-University that is one of the six largest faculties of human medicine in Germany and a member of the scientific elite in both basic and clinical research. With 40 clinical departments, about 54.000 inpatients and 121.000 outpatients per year, the UMG is a central focus in health care in Lower Saxony, Germany. A major objective of UMG research is to drive the translation of basic and preclinical research results into clinical practice. The UMG houses several research departments with state-of-the-art equipment and works in close collaboration with a number of non-university partners, such as three different Max-Planck Institutes, the German Primate Center and the European Neuroscience Institute (ENI). These interdisciplinary research networking activities have majorly contributed to the high national and international ranking of the University.

Prof. Frauke Alves, Dept. of Haematology and Oncology, leads an interdisciplinary imaging group with the focus on preclinical research. The main goal of the group is the investigation of mechanisms of disease progression and the development of novel therapies in small animal models. To optimize the concept of novel therapies and assess their preclinical efficacy, non-invasive optical imaging techniques in combination with novel fluorescent probes, as well as computed tomography are applied. Further resources available are state-of-the-art microCT, SPECT and bioluminescence imager. A close collaboration also exists with the Elettra synchrotron in Trieste, Italy.

MOVERIM - MOVERIM CONSULTING SPRL Square Ambiorix, 32 B.te 43 B1000 – Bruxelles

CONTACT PERSON Laura Vivani

Moverim premises are in Brussels, it has been created in 2001 thanks to the professionality and experience accumulated by its founders since early ‘90s in raising and managing funds for R&D of many clients like European universities, Research Centre’s, SMEs, non‐profit organisations, industries. Moverim is willing to fully participating in the projects assuring assistance coordination on training activities to all beneficiaries. The SME will organise mainly the training activitiy and contribute to dissemination strategy and the results exploitation, raising the capacity specifically required to get the best value from European projects, investigating commercial and philanthropic opportunities to give sustainability in order to keep the group research activity alive beyond the EU project financing.

PROMOSCIENCE - PROMOSCIENCE SRL AREA Science Park - Padriciano, 99 - Trieste (TS)

CONTACT PERSON Riccardo Brancaleon

Promoscience is a spin‐off of SISSA - International School of Advanced Studies in Trieste, founded in May 2004 by a team of researchers specialised in exploring the requirements of the scientific community, perfecting new and effective knowledge transmission strategies and developing adapted content management systems. The company develops innovative web based software for sharing objectives, managing activities and spreading results among the scientific communities. Promoscience’s product line includes Netscience, a Content Management tool for scientific dissemination and project management aimed at supporting the management of scientific projects. With the skills and experience of its team, Promoscience offers a successful and highly qualified consultancy service, able to satisfy the specific needs of Research Organisations, Universities, Business Support Agencies, Scientific Parks and Public Administrations.